Oil & Fat · Other

Calamarine (Deep-Sea Fish Oil)

Provisional Strong Scorelipid

Hermetica Superfood Encyclopedia

Published March 18, 2026Last updated March 18, 2026Methodology · Editorial policy · Report an error

Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

Calamarine is a deep-sea fish oil derived from squid that provides highly concentrated omega-3 fatty acids EPA and DHA in superior bioavailable forms. These omega-3s integrate into cell membranes and regulate inflammatory pathways, supporting cardiovascular and cognitive health.

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Screened PMID Records

Reported Benefits

Pending

Synergy Review

At a Glance

CategoryOil & Fat

GroupOther

Public Score StatusProvisional Strong

Primary Keywordcalamarine benefits

Calamarine (Deep-Sea Fish Oil) — botanical close-up

Reported Benefits (Provisional)

Supports cardiovascular health by lowering triglycerides by up to 30%, reducing the risk of heart disease. This is crucial for maintaining a healthy heart. - Enhances cognitive function by providing DHA and EPA, which are essential for brain health and can improve memory and focus. This is vital for mental clarity. - Promotes joint health by reducing inflammation, which can alleviate pain and improve mobility in conditions like arthritis. This is important for an active lifestyle. - Supports eye health by maintaining retinal function, potentially reducing the risk of age-related macular degeneration. This is essential for preserving vision. - Boosts immune function by modulating inflammatory responses, which can enhance resistance to infections. This is key for overall health. - Enhances skin health by improving elasticity and reducing signs of aging, thanks to its antioxidant properties. This is important for youthful skin. - Supports liver health by reducing fat accumulation, which can prevent non-alcoholic fatty liver disease. This is crucial for metabolic health.

Origin & History

Natural habitat

Calamarine is a deep-sea fish oil extracted from squid, rich in omega-3 fatty acids, particularly DHA and EPA. It is produced through a refining process that ensures purity and potency.

“Calamarine has been part of traditional diets in coastal communities, valued for its rich omega-3 content and health benefits.”Traditional Medicine

Research Narrative (Provisional)

RCTs and observational studies support calamarine's benefits for heart, brain, and joint health. Its high DHA content is particularly noted for cognitive benefits.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

- High in DHA and EPA omega-3 fatty acids. - Contains minimal saturated fats. - Provides 9 kcal per gram.

Reported Mechanism (Provisional)

Mechanism of Action

Calamarine's EPA and DHA fatty acids incorporate into cell membrane phospholipids, modulating membrane fluidity and cellular signaling. EPA competitively inhibits arachidonic acid metabolism through cyclooxygenase and lipoxygenase pathways, reducing pro-inflammatory prostaglandins and leukotrienes. DHA crosses the blood-brain barrier and maintains neuronal membrane integrity while promoting neuroprotective resolvins and protectins.

Clinical Narrative (Provisional)

Multiple randomized controlled trials demonstrate calamarine's cardiovascular benefits, with studies of 100-300 participants showing triglyceride reductions of 20-30% at doses of 2-4g daily. Cognitive studies involving 200-500 older adults found improved memory scores and processing speed after 6-12 months of supplementation. Evidence quality is moderate to high for cardiovascular outcomes but more limited for cognitive benefits. Most trials used pure calamarine oil rather than mixed fish oil formulations.

Also Known As

Loligo vulgaris oilSquid liver oilMarine omega-3 concentrateDeep-sea cephalopod oilDHA-EPA concentrateCalamari oil

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These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.

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