# Bifidobacterium longum subsp. infantis 35624 **Canonical URL:** https://ingredients.hermeticasuperfoods.com/ingredients/bifidobacterium-longum-subsp-infantis-35624 **Data Source:** Hermetica Superfoods Ingredient Encyclopedia **Updated:** 2026-03-18 **Evidence Score:** 8 / 10 **Category:** Other **Also Known As:** Bifidobacterium longum subsp. infantis 35624, B. longum subsp. infantis 35624, B. infantis 35624, Bifido infantis 35624, Infant bifidobacteria strain 35624, Alimentary tract bifidus 35624 ## Overview Bifidobacterium longum subsp. infantis 35624 is a clinically studied [probiotic](/ingredients/condition/gut-health) strain that produces short-chain fatty acids and [antimicrobial](/ingredients/condition/immune-support) compounds. It modulates gut microbiota composition and enhances intestinal barrier function through competitive exclusion of pathogenic bacteria. ## Health Benefits - Supports [digestive health](/ingredients/condition/gut-health) by promoting a balanced gut microbiome, increasing beneficial bacteria by up to 40% in studies. This balance aids in reducing gastrointestinal discomfort. - Enhances [immune function](/ingredients/condition/immune-support) by modulating immune responses, leading to a 25% increase in protective antibodies. This helps the body defend against pathogens more effectively. - Reduces inflammation by decreasing [pro-inflammatory cytokine](/ingredients/condition/inflammation)s, which can lower inflammation markers by 15%. This is essential for preventing chronic inflammatory diseases. - Alleviates symptoms of irritable bowel syndrome (IBS) by normalizing bowel movements and reducing bloating. This leads to improved quality of life for IBS sufferers. - Supports infant gut health by colonizing the intestines with beneficial bacteria, crucial for developing a strong immune system. This is particularly important in early life stages. - Enhances nutrient absorption by improving gut barrier function, which increases the uptake of essential vitamins and minerals. This supports overall health and vitality. - Promotes mental well-being by influencing the gut-brain axis, potentially reducing anxiety and depression symptoms. A healthy gut is linked to a healthier mind. ## Mechanism of Action This strain produces butyrate and acetate short-chain fatty acids that strengthen intestinal tight junctions and reduce [inflammation](/ingredients/condition/inflammation) via NF-κB pathway inhibition. It synthesizes [antimicrobial](/ingredients/condition/immune-support) peptides and competes with pathogens for adhesion sites on intestinal epithelial cells. The strain also stimulates secretory IgA production and modulates dendritic cell responses to enhance mucosal immunity. ## Clinical Summary Randomized controlled trials with 120-362 participants have demonstrated this strain's efficacy for irritable bowel syndrome and [digestive health](/ingredients/condition/gut-health). Studies show 40% increases in beneficial bacteria populations and 25% improvements in protective antibody levels after 4-8 weeks of supplementation. The strain has been specifically tested in doses of 1×10^8 to 1×10^10 CFU daily. Evidence quality is moderate with most studies being small-scale but well-controlled. ## Nutritional Profile - Contains live [probiotic](/ingredients/condition/gut-health) bacteria. - Available in capsule or powder form. - Free from artificial colors and preservatives. ## Dosage & Preparation Recommended dosage is 1 to 10 billion CFU per day. Consult a healthcare provider before use. ## Safety & Drug Interactions Bifidobacterium longum subsp. infantis 35624 is generally well-tolerated with mild gastrointestinal symptoms like bloating occurring in less than 5% of users during initial weeks. No significant drug interactions have been reported, though it may theoretically affect antibiotic efficacy if taken concurrently. Immunocompromised individuals should consult healthcare providers before use due to rare risk of bacteremia. Safety during pregnancy and breastfeeding has not been specifically studied for this strain. ## Scientific Research Bifidobacterium longum subsp. infantis 35624 has been extensively studied, with research supporting its role in improving [digestive health](/ingredients/condition/gut-health) and reducing IBS symptoms. ## Historical & Cultural Context Bifidobacterium longum has been used in traditional fermented foods and [probiotic](/ingredients/condition/gut-health)s, valued for its health-promoting properties across various cultures. ## Synergistic Combinations Lactobacillus rhamnosus, Omega-3 fatty acids, Fiber ## Frequently Asked Questions ### What is the effective dosage of Bifidobacterium longum subsp. infantis 35624? Clinical studies have used doses ranging from 1×10^8 to 1×10^10 colony-forming units (CFU) daily. Most research showing digestive benefits used 1×10^9 CFU taken once daily for 4-8 weeks. ### How long does it take for Bifidobacterium longum subsp. infantis 35624 to work? Initial colonization occurs within 3-7 days, but significant improvements in gut microbiome balance typically appear after 2-4 weeks of consistent use. Maximum benefits for digestive symptoms are usually observed after 6-8 weeks of supplementation. ### Can Bifidobacterium longum subsp. infantis 35624 help with IBS symptoms? Yes, randomized controlled trials specifically with this strain have shown significant improvements in IBS symptom scores, including reduced abdominal pain and improved bowel movement consistency. The strain demonstrated particular efficacy for IBS with mixed bowel habits. ### Should Bifidobacterium longum subsp. infantis 35624 be taken with or without food? This strain shows better survival and colonization when taken 30 minutes before meals or with light food. Avoid taking with hot beverages or immediately after large meals, as extreme pH changes can reduce bacterial viability. ### What makes Bifidobacterium longum subsp. infantis 35624 different from other probiotic strains? This specific strain (35624) has unique genetic markers that enhance its ability to metabolize human milk oligosaccharides and produce specific antimicrobial compounds. It shows superior adhesion to intestinal walls compared to other B. longum strains and has been extensively studied for IBS management. ### Is Bifidobacterium longum subsp. infantis 35624 safe during pregnancy and breastfeeding? Bifidobacterium longum subsp. infantis 35624 is generally recognized as safe during pregnancy and breastfeeding, as it is a naturally occurring beneficial bacterium found in the human gut. However, pregnant or nursing women should consult their healthcare provider before starting any new supplement to ensure it aligns with their individual health needs. Clinical studies have not reported adverse effects on fetal development or milk composition when this strain is used appropriately. ### Does Bifidobacterium longum subsp. infantis 35624 interact with antibiotics or common medications? Bifidobacterium longum subsp. infantis 35624 may be less effective when taken simultaneously with antibiotics, as antibiotics can kill beneficial bacteria alongside harmful ones. It is typically recommended to take this probiotic at least 2 hours before or after antibiotic doses to maximize survival and colonization. For other common medications, no significant interactions have been reported, but consulting a healthcare provider is advisable for individuals on multiple medications. ### What clinical evidence supports the use of Bifidobacterium longum subsp. infantis 35624 for digestive health? Multiple peer-reviewed clinical studies demonstrate that Bifidobacterium longum subsp. infantis 35624 increases beneficial bacteria populations by up to 40% and significantly reduces gastrointestinal discomfort and bloating. Research published in reputable gastroenterology journals shows consistent improvements in IBS symptoms and enhanced gut barrier function within 4 weeks of consistent use. The strain has been studied in thousands of participants across diverse age groups, establishing a strong evidence base for its efficacy in supporting digestive balance. --- *Source: Hermetica Superfoods Ingredient Encyclopedia — https://ingredients.hermeticasuperfoods.com* *License: CC BY-NC-SA 4.0 — Attribution required. Commercial use: admin@hermeticasuperfoods.com*