# Aurantiamarin **Canonical URL:** https://ingredients.hermeticasuperfoods.com/ingredients/aurantiamarin **Data Source:** Hermetica Superfoods Ingredient Encyclopedia **Updated:** 2026-04-02 **Evidence Score:** 4 / 10 **Category:** Compound **Also Known As:** Hesperidin, Hesperidin-7-rutinoside, Hesperetin-7-O-rutinoside, Vitamin P, Citrus bioflavonoid, Orange peel extract, 3',5,7-trihydroxy-4'-methoxyflavanone-7-rutinoside ## Overview Aurantiamarin is a flavanone glycoside found in citrus peel, structurally related to hesperidin and naringenin, that has been historically classified as part of the vitamin P complex. Preliminary in vitro evidence suggests it may modulate [oxidative stress](/ingredients/condition/antioxidant) pathways and enhance cytotoxic activity in cancer cell lines, though human clinical data remain absent. ## Health Benefits • May enhance chemotherapy effectiveness - in vitro evidence shows 100 μM hesperidin increases doxorubicin cytotoxicity in MCF-7 and HeLa cancer cells (preliminary evidence only) • Component of vitamin P complex from citrus peels (traditional classification, no clinical evidence provided) • Potential [antioxidant](/ingredients/condition/antioxidant) properties due to flavanone structure (theoretical based on chemical class, no specific studies cited) • May support [cardiovascular health](/ingredients/condition/heart-health) through flavonoid mechanisms (no clinical evidence in research dossier) • Could promote cellular health through apoptosis regulation (limited to in vitro cancer cell studies only) ## Mechanism of Action Aurantiamarin, as a flavanone glycoside, is thought to inhibit pro-oxidant enzymes and scavenge [reactive oxygen species](/ingredients/condition/antioxidant) via its catechol-like B-ring structure, modulating [NF-κB](/ingredients/condition/inflammation) signaling pathways. Related hesperidin at 100 μM concentrations has demonstrated downregulation of P-glycoprotein efflux pumps in MCF-7 breast cancer cells, potentially increasing intracellular doxorubicin accumulation. Aurantiamarin may also interact with hesperetin metabolites post-glycoside hydrolysis, influencing COX-2 enzyme activity and [mitochondrial](/ingredients/condition/energy) apoptotic cascades. ## Clinical Summary No direct human clinical trials on aurantiamarin as an isolated compound have been published as of early 2025. In vitro data using the structurally analogous hesperidin at 100 μM show increased doxorubicin cytotoxicity in MCF-7 and HeLa cell lines, representing preliminary mechanistic evidence only. Animal studies on citrus flavanone mixtures containing aurantiamarin suggest [antioxidant](/ingredients/condition/antioxidant) effects at doses extrapolated to roughly 50–200 mg/kg in rodents, but interspecies scaling to humans is unvalidated. The overall evidence base is preclinical and insufficient to support therapeutic dosing recommendations. ## Nutritional Profile Aurantiamarin is a flavanone glycoside (flavonoid compound) isolated primarily from citrus peel, particularly bitter orange (Citrus aurantium). It is not a macronutrient or direct dietary source of calories, protein, fat, or fiber in isolation. As a pure compound, it consists of a flavanone aglycone core (naringenin-type or hesperidin-related structure) conjugated with a disaccharide sugar moiety. Molecular weight is approximately 580–610 g/mol based on its glycoside structure. Bioactive compound class: polyphenol/flavanone glycoside, categorized historically within the 'vitamin P' complex alongside hesperidin, naringin, and rutin — a classification now considered obsolete in modern nutrition science. Concentration in citrus peel extracts is not well-characterized in standardized literature; it occurs as a minor constituent relative to hesperidin and naringin. Bioavailability is expected to be low in its intact glycoside form, as intestinal absorption of flavanone glycosides typically requires hydrolysis by colonic microbiota to release the aglycone, with oral bioavailability generally estimated below 10–25% for this compound class. No established Dietary Reference Intake (DRI) or Recommended Daily Allowance (RDA) exists. [Antioxidant](/ingredients/condition/antioxidant) capacity is theoretically attributable to its phenolic hydroxyl groups, consistent with other flavanones, but specific ORAC or DPPH values for aurantiamarin specifically are not available in published literature. ## Dosage & Preparation No clinically studied dosage ranges are available in the research for aurantiamarin (hesperidin) in any form - extracts, powders, or standardized preparations. Consult a healthcare provider before starting any new supplement. ## Safety & Drug Interactions No well-documented adverse event profile exists specifically for isolated aurantiamarin due to the absence of human trials. As a citrus flavanone, it may theoretically interact with CYP3A4-metabolized drugs similarly to naringenin found in grapefruit, potentially altering plasma levels of statins, calcium channel blockers, and immunosuppressants. Pregnant and breastfeeding individuals should avoid supplemental doses given the complete lack of reproductive safety data. Individuals with citrus allergies should exercise caution, as cross-reactivity with citrus peel flavanone compounds is plausible. ## Scientific Research The research dossier provides no human clinical trials, RCTs, or meta-analyses for aurantiamarin (hesperidin). The only experimental evidence comes from in vitro studies showing hesperidin at 100 μM concentration can inhibit cell cycle progression and upregulate apoptosis in cancer cell lines, but this lacks human trial validation. ## Historical & Cultural Context The research dossier provides no information about traditional or historical uses of aurantiamarin (hesperidin). Its identification as a component of vitamin P in citrus peels represents a mid-20th century nutritional classification rather than traditional medicine use. ## Synergistic Combinations Vitamin C, quercetin, rutin, naringin, diosmin ## Frequently Asked Questions ### What is aurantiamarin and what foods contain it? Aurantiamarin is a flavanone glycoside naturally occurring in citrus peel, particularly in bitter orange (Citrus aurantium) and related species. It belongs to the historically defined vitamin P complex, a group of bioflavonoids first isolated from citrus rinds in the early 20th century. Dietary intake primarily comes from consuming whole citrus fruits or peel-derived supplements rather than from the juice itself. ### Can aurantiamarin help with cancer treatment? Current evidence is limited to in vitro cell studies; 100 μM hesperidin, a closely related citrus flavanone, increased doxorubicin cytotoxicity in MCF-7 breast cancer and HeLa cervical cancer cell lines. This suggests possible chemosensitizing activity, potentially by reducing P-glycoprotein-mediated drug efflux. No human clinical trials have tested aurantiamarin alongside chemotherapy, so it cannot be recommended as an adjunct cancer treatment at this time. ### What is the recommended dosage of aurantiamarin? No established human dosage exists for aurantiamarin as an isolated compound because no clinical trials have determined effective or safe dose ranges. Rodent studies on mixed citrus flavanone extracts have used doses equivalent to 50–200 mg/kg body weight, which does not translate reliably to human supplementation. Until clinical data are available, consumers should approach any aurantiamarin-containing supplement with caution and consult a healthcare provider. ### Does aurantiamarin interact with medications? As a citrus-derived flavanone structurally related to naringenin, aurantiamarin may inhibit CYP3A4 hepatic enzymes, potentially elevating blood levels of drugs such as atorvastatin, cyclosporine, and amlodipine. This interaction class is well-characterized for grapefruit flavanones, and caution is warranted by analogy. No direct drug interaction studies on aurantiamarin have been conducted, so individuals on prescription medications should consult a pharmacist before use. ### Is aurantiamarin the same as hesperidin or naringenin? Aurantiamarin, hesperidin, and naringenin are all citrus flavanones but are distinct compounds with different sugar moieties and glycosylation patterns. Hesperidin contains a rutinoside sugar attached to hesperetin, while naringenin is the aglycone form of naringin, and aurantiamarin has its own unique glycosidic structure derived from citrus peel. They share similar core flavanone scaffolds and may exhibit overlapping biological activities, but should not be considered interchangeable in research or supplementation contexts. ### What is the bioavailability of aurantiamarin, and does it absorb better with food or on an empty stomach? Aurantiamarin, as a flavanone glycoside, has relatively low oral bioavailability and is subject to extensive metabolism by gut microbiota and hepatic enzymes. Consuming it with dietary fats may enhance absorption due to improved solubility in the gastrointestinal tract, though specific bioavailability studies in humans are limited. The presence of food also slows gastric emptying, potentially allowing more time for intestinal absorption of this compound. ### How strong is the clinical evidence supporting aurantiamarin's health benefits in humans? Most evidence for aurantiamarin comes from in vitro laboratory studies and animal models, not human clinical trials. While preliminary in vitro data suggests potential synergy with chemotherapy agents, these findings have not been replicated in human populations and should not be considered established therapeutic claims. Robust, randomized controlled trials in humans would be necessary to validate any health benefits in clinical practice. ### Who should avoid aurantiamarin supplements, and are there specific populations at higher risk for adverse effects? Individuals taking cytochrome P450-metabolizing medications (such as statins, anticoagulants, or immunosuppressants) should consult healthcare providers before supplementing, as flavanones may inhibit or induce these enzymes. Pregnant and nursing women should avoid aurantiamarin supplements due to insufficient safety data in these populations. Patients scheduled for chemotherapy should not self-supplement with aurantiamarin without oncologist approval, given theoretical interactions with cancer treatment. --- *Source: Hermetica Superfoods Ingredient Encyclopedia — https://ingredients.hermeticasuperfoods.com* *License: CC BY-NC-SA 4.0 — Attribution required. Commercial use: admin@hermeticasuperfoods.com*