# Artemetin **Canonical URL:** https://ingredients.hermeticasuperfoods.com/ingredients/artemetin **Data Source:** Hermetica Superfoods Ingredient Encyclopedia **Updated:** 2026-03-29 **Evidence Score:** 2 / 10 **Category:** Compound **Also Known As:** 5,3',4'-trihydroxy-6,7,8-trimethoxyflavone, Artemisia flavonoid, Sweet wormwood flavonoid, Qinghao flavonoid, Artemetin flavonoid, 6,7,8-trimethoxy-5,3',4'-trihydroxyflavone ## Overview Artemetin is a polymethoxyflavonoid compound found in various plants that demonstrates anti-inflammatory and antidiabetic properties through modulation of immune cell activity and [glucose metabolism](/ingredients/condition/weight-management). Research shows it reduces airway inflammation by suppressing eosinophil infiltration and [pro-inflammatory cytokine](/ingredients/condition/inflammation) production. ## Health Benefits • Modulates airway inflammation and [mitochondrial](/ingredients/condition/energy) dysfunction in asthma models, reducing eosinophils and [pro-inflammatory cytokine](/ingredients/condition/inflammation)s (preclinical evidence).[3] • Potential anti-hepatocellular carcinoma effects suggested by in silico studies (requires validation).[4] • Antidiabetic potential through multitarget interactions with key metabolic proteins (in silico evidence).[4] • Synergizes with artemisinin to combat malaria parasites (inferred from plant profile).[4][9] • May reduce [oxidative stress](/ingredients/condition/antioxidant) and PANoptosis in inflammatory conditions (preclinical models).[3] ## Mechanism of Action Artemetin modulates inflammatory responses by inhibiting eosinophil recruitment and reducing production of [pro-inflammatory cytokine](/ingredients/condition/inflammation)s including IL-4, IL-5, and IL-13. The compound also demonstrates antidiabetic potential through enhancement of glucose uptake and [insulin sensitivity](/ingredients/condition/weight-management) pathways. Additionally, artemetin appears to protect [mitochondrial function](/ingredients/condition/energy) by reducing [oxidative stress](/ingredients/condition/antioxidant) and maintaining cellular energy metabolism. ## Clinical Summary Current evidence for artemetin comes primarily from preclinical animal studies and in silico computational research. Asthma model studies demonstrate significant reduction in airway [inflammation](/ingredients/condition/inflammation) markers and eosinophil counts compared to controls. In silico studies suggest potential anti-hepatocellular carcinoma activity, though this requires validation through clinical trials. Human clinical data is currently limited, with most evidence derived from laboratory and animal studies. ## Nutritional Profile Artemetin is a pure polymethoxylated flavonoid compound (5,7-dihydroxy-3,4',6-trimethoxyflavone), not a whole food or ingredient with a traditional macronutrient/micronutrient profile. As an isolated bioactive compound, it does not contain proteins, carbohydrates, fats, or dietary fiber in a nutritional sense. It is found naturally in trace concentrations in Artemisia species (e.g., Artemisia annua), Vitex agnus-castus, and certain citrus plants, where it typically occurs at concentrations of 0.01–0.5% dry weight depending on plant source and extraction method. Artemetin has a molecular weight of 372.37 g/mol and molecular formula C19H18O7. Its bioavailability is characteristically limited due to low aqueous solubility (as with most polymethoxylated flavonoids), but methoxyl substitutions at the 3, 4', and 6 positions relative to non-methylated flavonoids generally improve lipid solubility and intestinal membrane permeability compared to hydroxylated analogs like luteolin. Oral bioavailability is estimated to be low in absolute terms (likely <10% based on class-level pharmacokinetic data for polymethoxylated flavonoids), with hepatic first-pass [metabolism](/ingredients/condition/weight-management) involving demethylation and glucuronidation as primary metabolic pathways. No established dietary reference intake or therapeutic dosage has been formally defined. It is consumed only as a phytochemical constituent within botanical preparations, not as a standalone nutritional ingredient. ## Dosage & Preparation No clinically studied dosage ranges for artemetin in humans exist, and preclinical studies do not quantify doses. Consult a healthcare provider before starting any new supplement. ## Safety & Drug Interactions Safety data for artemetin supplementation in humans is limited due to lack of clinical trials. No specific drug interactions have been documented, though potential exists for interactions with diabetes medications due to glucose-lowering effects. Pregnant and breastfeeding women should avoid artemetin supplements due to insufficient safety data. Individuals with existing liver conditions should consult healthcare providers before use given the compound's hepatic [metabolism](/ingredients/condition/weight-management) pathways. ## Scientific Research No human clinical trials, RCTs, or meta-analyses specifically on artemetin were identified. Preclinical studies focus on its effects in asthma models and in silico analyses suggest potential in cancer and diabetes treatment.[1][2][3][4] ## Historical & Cultural Context Artemetin derives from Artemisia annua, used in Traditional Chinese Medicine for over 2,000 years to treat fevers, malaria, and [inflammatory](/ingredients/condition/inflammation) conditions. Though artemetin itself is not explicitly documented, its activity is inferred from the plant's flavonoid profile. ## Synergistic Combinations Artemisinin, casticin, EGCG, quercetin, resveratrol ## Frequently Asked Questions ### What foods contain artemetin naturally? Artemetin is found in citrus peels, particularly orange and tangerine peels, as well as in certain medicinal plants like Artemisia species. The compound is most concentrated in the outer rinds of citrus fruits and various traditional herbal medicines. ### How much artemetin should I take daily? No standardized dosage exists for artemetin supplements due to limited human studies. Research doses in animal studies typically range from 10-50mg per kilogram of body weight, but human equivalent doses have not been established through clinical trials. ### Can artemetin help with asthma symptoms? Preclinical studies show artemetin reduces airway inflammation by decreasing eosinophil infiltration and pro-inflammatory cytokines IL-4, IL-5, and IL-13. However, human clinical trials are needed to confirm these anti-asthmatic effects and establish therapeutic protocols. ### Does artemetin interact with diabetes medications? While no specific interactions are documented, artemetin shows glucose-lowering effects in preclinical studies that could potentially enhance diabetes medication effects. Diabetic patients should monitor blood sugar closely and consult healthcare providers before supplementation. ### Is artemetin the same as artemisinin? No, artemetin and artemisinin are different compounds despite similar names. Artemetin is a polymethoxyflavonoid with anti-inflammatory properties, while artemisinin is a sesquiterpene lactone primarily used as an antimalarial drug with different molecular structure and mechanisms. ### What does current research show about artemetin's effectiveness for liver health? In silico (computer modeling) studies suggest artemetin may have potential anti-hepatocellular carcinoma properties by interacting with cancer-related molecular pathways, but these findings remain theoretical and have not been validated in human clinical trials. Animal and cell-based studies would be needed before any therapeutic claims can be established. Currently, there is insufficient clinical evidence to recommend artemetin specifically for liver disease prevention or treatment. ### Who should avoid taking artemetin supplements? Individuals with bleeding disorders or those taking anticoagulant medications should consult a healthcare provider before using artemetin, as flavonoid compounds may affect platelet function. Pregnant and nursing women should avoid artemetin due to lack of safety data in these populations. People with known allergies to Artemisia species or related plants should also exercise caution. ### How does artemetin absorption and bioavailability compare to other flavonoids? Like most flavonoids, artemetin has limited oral bioavailability due to poor intestinal absorption and extensive first-pass metabolism, meaning a significant portion may not reach systemic circulation. The bioavailability of artemetin specifically has not been extensively characterized in human studies, making direct comparisons to other flavonoids difficult. Consumption with dietary fats and certain food components may enhance absorption, though specific data for artemetin remains limited. --- *Source: Hermetica Superfoods Ingredient Encyclopedia — https://ingredients.hermeticasuperfoods.com* *License: CC BY-NC-SA 4.0 — Attribution required. Commercial use: admin@hermeticasuperfoods.com*