# Andean Nettle

**Canonical URL:** https://ingredients.hermeticasuperfoods.com/ingredients/andean-nettle
**Data Source:** Hermetica Superfoods Ingredient Encyclopedia
**Updated:** 2026-03-15
**Evidence Score:** 4 / 10
**Category:** Leaf/Green
**Also Known As:** Urtica dioica L., Stinging nettle, Urtica dioica var. andicola, Common nettle

## Overview

Andean Nettle (Urtica dioica) contains bioactive flavonoids including apigenin, luteolin, and quercetin that suppress inflammatory cytokines TNF-α by 50.8% and IL-1β by 99.7% through NF-κB pathway inhibition. The herb demonstrates potent [anti-inflammatory](/ingredients/condition/inflammation) activity by inhibiting COX-1 (IC₅₀ 160 µg/mL), COX-2 (IC₅₀ 275 µg/mL), and histamine H1 receptors.

## Health Benefits

- **Enhances [immune function](/ingredients/condition/immune-support)**: and [collagen synthesis](/ingredients/condition/skin-health) through its high Vitamin C content.
- **Supports healthy oxygen**: transport and [energy production](/ingredients/condition/energy) by providing essential iron.
- **Promotes [muscle relaxation](/ingredients/condition/sleep)**: and nervous system regulation via its magnesium content.
- **Reduces [oxidative stress](/ingredients/condition/antioxidant)**: and [inflammation](/ingredients/condition/inflammation) through a rich profile of flavonoids.
- **Supports cellular detoxification**: and [liver function](/ingredients/condition/detox) with its chlorophyll content.

## Mechanism of Action

Flavonoids like apigenin and quercetin inhibit pro-[inflammatory pathway](/ingredients/condition/inflammation)s by preventing NF-κB activation and blocking COX-1/COX-2 enzymes with IC₅₀ values of 160-275 µg/mL. Phenolic compounds including vanillic acid enhance antioxidant enzyme systems (superoxide dismutase, catalase, [glutathione](/ingredients/condition/detox) peroxidase) while reducing [lipid peroxidation](/ingredients/condition/antioxidant). The nettle hairs contain [acetylcholine](/ingredients/condition/cognitive), histamine, and [serotonin](/ingredients/condition/mood) that trigger initial inflammatory responses upon contact.

## Clinical Summary

Current evidence derives exclusively from in vitro and animal studies, with no published human clinical trials available. Laboratory studies show ethanol extracts at 5 mg/mL suppress [inflammatory](/ingredients/condition/inflammation) cytokines TNF-α and IL-1β in human blood samples after 24-hour LPS stimulation. Animal studies using 50-100 mg/kg doses for 14 days in mice demonstrate enhanced antioxidant enzyme activity and reduced [oxidative stress](/ingredients/condition/antioxidant) markers. The [antimicrobial](/ingredients/condition/immune-support) effects show variable potency with MIC values ranging from 0.13-16.33 mg/mL against different bacterial strains, indicating modest antibacterial activity.

## Nutritional Profile

- Vitamins: Vitamin C
- Minerals: Iron, Magnesium
- Phytochemicals: Flavonoids, Chlorophyll

## Dosage & Preparation

- Infusion: Brew 1-2 teaspoons of dried leaves into a tea for daily detoxification and [anti-inflammatory](/ingredients/condition/inflammation) support.
- Whole Food: Incorporate fresh leaves into soups, stews, or stir-fries as a nutrient-dense green.
- Extracts: Consume standardized tinctures or capsules as directed for concentrated [adaptogen](/ingredients/condition/stress)ic benefits.

## Safety & Drug Interactions

Direct contact with fresh nettle hairs causes skin irritation due to formic acid, histamine, [acetylcholine](/ingredients/condition/cognitive), and [serotonin](/ingredients/condition/mood) content in the stinging trichomes. Processed extracts appear well-tolerated in laboratory studies and demonstrate protective effects against oxidative damage in human skin fibroblasts. No specific drug interactions or contraindications are documented in available research. Clinical safety data remains limited due to absence of human trials, requiring cautious use and professional guidance.

## Scientific Research

While traditionally revered in Andean medicine for joint pain, kidney issues, and skin conditions, scientific research specifically on Urtica dioica var. andicola is emerging. Studies on related nettle species (Urtica dioica) support [anti-inflammatory](/ingredients/condition/inflammation) and diuretic properties, suggesting similar benefits for Andean Nettle. Further targeted research is needed to fully elucidate its unique pharmacological profile.

## Historical & Cultural Context

Andean Nettle has been a cornerstone of traditional Andean medicine for centuries, particularly among indigenous communities in Peru and Ecuador. It was historically used to treat joint pain, kidney issues, and skin conditions, and revered for enhancing [stamina](/ingredients/condition/energy) and vitality in high-altitude environments.

## Synergistic Combinations

Role: Mineral cofactor
Intention: Immune & [Inflammation](/ingredients/condition/inflammation) | Detox & Liver
Primary Pairings: Spirulina (Arthrospira platensis); Ginger (Zingiber officinale); Ashwagandha (Withania somnifera)

## Frequently Asked Questions

### What are the main bioactive compounds in Andean Nettle?

Andean Nettle contains flavonoids (apigenin, luteolin, quercetin, rutin, kaempferol), phenolic acids (p-hydroxybenzoic acid, vanillic acid), carotenoids, and terpenoids. The stinging hairs contain formic acid, acetylcholine (1%), histamine, and serotonin that cause the characteristic burning sensation.

### How effective is Andean Nettle for inflammation?

Laboratory studies show ethanol extracts suppress TNF-α by 50.8% and IL-1β by 99.7% in human blood samples. The anti-inflammatory activity includes COX-1 and COX-2 inhibition with IC₅₀ values of 160-275 µg/mL, though human clinical trials are lacking.

### Is Andean Nettle safe to consume?

Fresh nettle causes skin irritation from stinging hairs containing histamine and formic acid. Processed extracts appear safe in laboratory studies and protect against cellular damage, but comprehensive human safety data is limited due to lack of clinical trials.

### What's the difference between Andean Nettle and regular stinging nettle?

Andean Nettle refers to Urtica dioica growing in high-altitude Andean regions, potentially as variety andicola. No distinct biochemical differences are documented in research, suggesting similar bioactive profiles to standard Urtica dioica found globally.

### What is the recommended dosage for Andean Nettle?

Animal studies used 50-100 mg/kg daily for 14 days showing antioxidant benefits, but no established human dosing guidelines exist. Clinical trials are needed to determine safe and effective dosages for therapeutic use in humans.

### Can Andean Nettle help support energy levels and athletic performance?

Yes, Andean Nettle's iron content supports healthy oxygen transport throughout the body, which is essential for sustained energy production and physical endurance. The mineral-rich profile also includes magnesium, which plays a role in muscle function and energy metabolism, making it potentially beneficial for those engaging in regular physical activity.

### Does Andean Nettle interact with blood thinners or anticoagulant medications?

While Andean Nettle is generally safe, its vitamin K content may theoretically interact with blood-thinning medications like warfarin. If you take anticoagulants or antiplatelet drugs, consult your healthcare provider before adding Andean Nettle supplementation to ensure safe concurrent use.

### Who would benefit most from taking Andean Nettle as a supplement?

Andean Nettle is particularly beneficial for individuals seeking immune support, those with high oxidative stress or inflammatory conditions, and people with low iron or magnesium levels. Athletes, those recovering from illness, and individuals prioritizing collagen and connective tissue health may also find supplementation especially valuable.

## References

Sources: https://pubmed.ncbi.nlm.nih.gov/27422215; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579657; https://www.sciencedirect.com/science/article/pii/S2210803315000793

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