Enzyme

Aldolase

Provisional Moderate ScoreCompound

Hermetica Superfood Encyclopedia

Published March 15, 2026Last updated March 15, 2026Methodology · Editorial policy · Report an error

Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

Aldolase, primarily fructose-1,6-bisphosphate aldolase, is a crucial enzyme that catalyzes the reversible aldol cleavage of fructose-1,6-bisphosphate (F1,6BP). This action splits F1,6BP into glyceraldehyde-3-phosphate (G3P) and dihydroxyacetone phosphate (DHAP), a key step in glycolysis for cellular energy production.

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Screened PMID Records

Reported Benefits

Pending

Synergy Review

At a Glance

CategoryEnzyme

GroupEnzyme

Public Score StatusProvisional Moderate

Primary Keywordwhat is Aldolase

Aldolase — botanical close-up

Reported Benefits (Provisional)

Supports cellular energy production by facilitating a key reaction in glycolysis for ATP synthesis.

Promotes muscle endurance and contraction by sustaining ATP supply during physical exertion.

Aids brain function by ensuring a steady supply of glucose-derived energy to neurons.

Regulates overall carbohydrate metabolism, ensuring efficient bioenergetic flow

Enhances exercise performance by enabling rapid glucose utilization in muscle cells.

Origin & History

Natural habitat

Aldolase (EC 4.1.2.13) is a glycolytic enzyme ubiquitously present in human tissues, particularly abundant in muscle, liver, and brain. It catalyzes the reversible cleavage of fructose-1,6-bisphosphate into dihydroxyacetone phosphate and glyceraldehyde-3-phosphate. This critical step in glucose metabolism is essential for efficient ATP production and cellular energy supply.

“Modern biochemical compound without traditional medicinal history. Aldolase was discovered and characterized in the early 20th century, providing a crucial understanding of glucose breakdown. While not explicitly named in ancient systems, its role in energy metabolism aligns with traditional concepts of vital energy, such as Ayurvedic "ojas" and Traditional Chinese Medicine’s "qi" flow, both linked to cellular vitality and strength.”Traditional Medicine

Research Narrative (Provisional)

Aldolase is extensively studied for its fundamental biochemical role in glycolysis and carbohydrate metabolism. Research, including clinical and molecular studies, highlights its relevance in metabolic myopathies, cancer metabolism, and neurodegenerative conditions. Elevated aldolase levels are a recognized diagnostic biomarker for muscular dystrophies and various liver pathologies.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

- Catalyzes the cleavage of fructose-1,6-bisphosphate. - Produces dihydroxyacetone phosphate and glyceraldehyde-3-phosphate. - Requires no cofactors for its catalytic activity. - Exists in multiple isoforms (Aldolase A, B, C) with tissue-specific expression.

Reported Mechanism (Provisional)

Mechanism of Action

Aldolase, specifically fructose-1,6-bisphosphate aldolase (FBA), catalyzes the reversible aldol cleavage of fructose-1,6-bisphosphate (F1,6BP). This central step in glycolysis splits F1,6BP into glyceraldehyde-3-phosphate (G3P) and dihydroxyacetone phosphate (DHAP), essential precursors for ATP synthesis. In Class I aldolases, this mechanism involves a lysine residue forming a covalent Schiff base intermediate with the substrate carbonyl group.

Clinical Narrative (Provisional)

Aldolase is extensively studied for its fundamental role in glycolysis and carbohydrate metabolism, with clinical research highlighting its relevance in various pathological conditions. Elevated aldolase levels, particularly in serum, are a recognized biomarker for muscle damage, metabolic myopathies, and certain types of cancer, reflecting increased cellular breakdown or altered metabolism. Research also explores its involvement in cancer metabolism and neurodegenerative conditions, positioning aldolase as a diagnostic and prognostic indicator in these areas.

Also Known As

Fructose-1,6-bisphosphate aldolaseFructose-bisphosphate aldolaseFBAEC 4.1.2.13

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These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.

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