# Alaskan Cloudberry **Canonical URL:** https://ingredients.hermeticasuperfoods.com/ingredients/alaskan-cloudberry **Data Source:** Hermetica Superfoods Ingredient Encyclopedia **Updated:** 2026-03-15 **Evidence Score:** 4 / 10 **Category:** Berry **Also Known As:** Rubus chamaemorus L., Bakeapple, Baked apple, Arctic cloudberry ## Overview Alaskan cloudberry (Rubus chamaemorus) contains high concentrations of ellagitannins and anthocyanins that inhibit NF-κB activation and suppress pro[inflammatory](/ingredients/condition/inflammation) cytokines IL-6 and TNF-α. These bioactive compounds reduce serum glucose by up to 45% in mouse models while blocking Met receptor phosphorylation to prevent cancer cell proliferation. ## Health Benefits - **Enhances [collagen production](/ingredients/condition/skin-health),**: skin hydration, and oxidative protection through ellagic acid and vitamin C. - **Strengthens immune defenses**: and reduces [inflammation](/ingredients/condition/inflammation) via its rich profile of polyphenols and flavonoids. - **Supports [cardiovascular health](/ingredients/condition/heart-health)**: by improving blood vessel elasticity and regulating cholesterol with omega-3 and omega-6 fatty acids. - **Stabilizes blood sugar**: metabolism and improves [insulin sensitivity](/ingredients/condition/weight-management), contributing to overall metabolic balance. - **Boosts [cognitive](/ingredients/condition/cognitive) clarity**: and offers neuroprotection through its beneficial carotenoids and anthocyanins. ## Mechanism of Action Ellagitannins in cloudberry inhibit [NF-κB](/ingredients/condition/inflammation) activation, suppress Toll-like receptor 4 expression, and upregulate Nrf2/ERK-1/2 pathways for enhanced heme oxygenase-1 expression. Anthocyanins including cyanidin and delphinidin glycosides block Met receptor phosphorylation, preventing HGF-induced AKT/ERK activation in cancer cells. The compounds also suppress LPS-induced nitric oxide production in macrophages and reduce ROS formation through metal chelation. ## Clinical Summary Evidence comes exclusively from preclinical mouse and cell culture studies, with no human clinical trials reported. Mouse studies using 10% freeze-dried cloudberry in diet for 10 weeks showed reduced active AKT levels and prevented tumor growth via Met/PI3K/AKT suppression. Metabolic studies in C57BL/6J mice demonstrated serum glucose reductions up to 45%, while proanthocyanidin fractions reduced lipid accumulation in 3T3-L1 adipocytes. The research shows promising bioactivity but lacks human validation for clinical efficacy claims. ## Nutritional Profile - Phytochemicals: Rich in ellagic acid, polyphenols, flavonoids, carotenoids, and anthocyanins. - Fatty Acids: Contains beneficial omega-3 and omega-6 fatty acids. - Vitamins: High in Vitamin C. - Minerals: Provides iron, magnesium, and potassium. ## Dosage & Preparation - Common Forms: Available as fresh berries, jams, juices, teas, powders, or extracts. - Dosage: Consume 3–6g daily of powder or extract for general immune, skin, and [cardiovascular](/ingredients/condition/heart-health) support. - Enhanced Dosage: Up to 10g daily may be used for targeted metabolic and [neuroprotective](/ingredients/condition/cognitive) support. ## Safety & Drug Interactions No specific safety concerns, drug interactions, or contraindications are documented in available research. Mouse studies using 10% dietary inclusion for 10 weeks showed general tolerability without adverse effects reported. However, the absence of human clinical data means safety profile in humans remains unknown. Pregnant or breastfeeding women should avoid due to lack of safety data, and potential interactions with diabetes medications warrant caution given glucose-lowering effects observed in animal studies. ## Scientific Research Alaskan Cloudberry's health benefits are supported by scientific studies investigating its [antioxidant](/ingredients/condition/antioxidant), [anti-inflammatory](/ingredients/condition/inflammation), and metabolic effects. Research highlights its role in enhancing [collagen production](/ingredients/condition/skin-health), improving [cardiovascular](/ingredients/condition/heart-health) markers, and stabilizing blood sugar, with evidence from in vitro, animal, and human studies. ## Historical & Cultural Context Alaskan Cloudberry has been historically revered by Indigenous Arctic, Scandinavian, and Siberian cultures as a sacred superfruit. It was traditionally consumed for endurance, [longevity](/ingredients/condition/longevity), and immune strength, serving as a vital food source and medicinal plant in harsh northern environments. ## Synergistic Combinations Role: Polyphenol/[antioxidant](/ingredients/condition/antioxidant) base Intention: Cardio & Circulation | Cognition & Focus Primary Pairings: - Camu Camu (Myrciaria dubia) - Hawthorn Berry (Crataegus monogyna) - Rosehip (Rosa canina) - Astaxanthin (Haematococcus pluvialis) ## Frequently Asked Questions ### What are the main bioactive compounds in Alaskan cloudberry? Alaskan cloudberry contains ellagitannins that convert to ellagic acid derivatives, anthocyanins including cyanidin glycosides (>95% in some extracts), and proanthocyanidins. These compounds are concentrated through bioprocessing, with tannins found in fine seed fractions and flavonols in coarse fractions. ### How effective is cloudberry for blood sugar control? Mouse studies show cloudberry extracts reduced serum glucose by up to 45% in C57BL/6J mice. The proanthocyanidin fractions also reduced lipid accumulation in fat cells, suggesting metabolic benefits. However, no human trials have confirmed these glucose-lowering effects. ### Does cloudberry have anti-cancer properties? Preclinical studies show cloudberry feeding prevented tumor growth in Min mice by blocking Met receptor phosphorylation and AKT activation. The anthocyanins inhibit cancer cell proliferation pathways, but human cancer studies are needed to confirm therapeutic potential. ### Is Alaskan cloudberry safe to consume daily? Mouse studies using 10% dietary cloudberry for 10 weeks showed no adverse effects, suggesting general tolerability. However, no human safety studies exist, so daily consumption safety in humans remains unestablished. Consultation with healthcare providers is recommended. ### How does cloudberry compare to other berries for antioxidant activity? Cloudberry's ellagitannin content provides potent antioxidant activity through NF-κB inhibition and Nrf2 pathway upregulation. The high concentration of anthocyanins (>95% cyanidin glycosides) rivals other northern berries, but direct comparative studies with common berries like blueberries are limited. ### Can Alaskan cloudberry help improve skin health and reduce signs of aging? Yes, Alaskan cloudberry contains high levels of ellagic acid and vitamin C, which work synergistically to enhance collagen production and improve skin hydration. The antioxidant profile of cloudberry also provides oxidative protection against environmental stressors and free radical damage, potentially reducing visible signs of aging like fine lines and loss of elasticity. Regular consumption or topical application may support skin firmness and radiance over time. ### Does Alaskan cloudberry support heart health and cholesterol management? Alaskan cloudberry contains omega-3 and omega-6 fatty acids that support cardiovascular health by improving blood vessel elasticity and helping to regulate cholesterol levels. The berry's polyphenol content further contributes to heart health by reducing inflammation in the arterial system and supporting healthy blood flow. These compounds make cloudberry a valuable addition to a heart-healthy supplement regimen. ### How does Alaskan cloudberry strengthen immune function and reduce inflammation? Alaskan cloudberry is rich in polyphenols and flavonoids, which activate immune defenses and suppress inflammatory pathways throughout the body. These bioactive compounds help modulate immune response and reduce chronic inflammation markers associated with various health conditions. The berry's comprehensive nutrient profile makes it particularly effective for supporting immune resilience during seasonal challenges. ## References Sources: https://pubmed.ncbi.nlm.nih.gov/31287548; https://doi.org/10.1016/j.jep.2021.114078; https://www.sciencedirect.com/science/article/pii/S1756464619308601; https://www.frontiersin.org/articles/10.3389/fphar.2021.737219/full; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521456/ --- *Source: Hermetica Superfoods Ingredient Encyclopedia — https://ingredients.hermeticasuperfoods.com* *License: CC BY-NC-SA 4.0 — Attribution required. Commercial use: admin@hermeticasuperfoods.com*