Herbs (Global Traditional) · Traditional Chinese Medicine
Agastache (Agastache rugosa) (Agastache rugosa)
Preliminary EvidenceCompound
Hermetica Superfood Encyclopedia
Agastache rugosa, known in Traditional Chinese Medicine as Huo Xiang, contains the primary bioactive compound rosmarinic acid along with essential oils including methylchavicol (estragole) and limonene. These compounds exert anti-inflammatory and gastroprotective effects by suppressing pro-inflammatory cytokine pathways and protecting gastric mucosal tissue.
Agastache rugosa, also known as Korean mint or giant hyssop, is a traditional medicinal plant native to East Asia. It is primarily used in the form of extracts, infusions, or essential oils derived from its leaves and stems.
The research lacks specific human clinical trials or meta-analyses with PubMed PMIDs. The primary evidence comes from in vitro and animal studies, indicating preliminary efficacy.
Animal studies suggest a dosage of 100 mg/kg/day for extracts in gastritis models. In vitro anti-inflammatory effects observed at 100-200 μg/mL. Consult a healthcare provider before starting any new supplement.
Agastache rugosa (Korean mint/Huo Xiang) is used primarily as a medicinal herb rather than a food source, so macronutrient data is limited; however, key compositional data is available. Bioactive compounds dominate its profile: the essential oil fraction (0.5–1.5% of dry weight) is rich in methylchavicol (estragole, 40–80% of essential oil), along with limonene (~5–15%), anisaldehyde, and β-caryophyllene. The aerial parts contain rosmarinic acid (a major phenolic acid, reported at approximately 1–3% of dry weight), acacetin (5,7-dihydroxy-4′-methoxyflavone), tilianin (acacetin-7-O-glucoside), and agastachoside. Total polyphenol content has been measured at roughly 20–50 mg GAE/g dry extract in standardized preparations. Flavonoid content includes luteolin and apigenin glycosides. The herb contains modest amounts of dietary fiber in whole dried form (~10–15% of dry weight as crude fiber). Mineral content includes calcium (~1,200–1,500 mg/100g dry), potassium (~1,800–2,200 mg/100g dry), magnesium (~200–300 mg/100g dry), and iron (~15–25 mg/100g dry), though these figures reflect dried herb concentrations not typical therapeutic doses. Vitamin content includes trace amounts of vitamin C and B-complex vitamins. Bioavailability note: rosmarinic acid demonstrates moderate oral bioavailability (~1–10% systemic absorption in human studies); essential oil constituents like methylchavicol are lipophilic and absorb readily through gastrointestinal membranes. Most therapeutic use involves aqueous decoctions (3–9g dried herb), significantly diluting absolute compound concentrations delivered per dose.
Rosmarinic acid in Agastache rugosa inhibits NF-κB signaling, reducing downstream production of pro-inflammatory mediators including nitric oxide (NO) via suppression of inducible nitric oxide synthase (iNOS) in macrophages. The essential oil constituent methylchavicol acts on 5-HT3 receptors and muscarinic pathways, which may underlie the herb's traditional anti-emetic application. Gastroprotective effects are partially attributed to enhanced prostaglandin E2 synthesis and increased mucin secretion, which reinforce the gastric mucosal barrier against ulcerogenic insults.
Preclinical animal studies demonstrated greater than 60% gastroprotective efficacy at 100 mg/kg/day in rodent models of experimentally induced gastritis, suggesting meaningful mucosal barrier reinforcement. In vitro cell-based assays using LPS-stimulated macrophages showed significant reduction in nitric oxide production, supporting an anti-inflammatory mechanism, though these findings have not yet been replicated in randomized controlled human trials. Human clinical evidence remains largely absent, with current support derived from traditional TCM use, animal models, and cell culture studies. The overall evidence base is preliminary, and well-designed clinical trials in human populations are needed before efficacy claims can be substantiated.
Agastache rugosa is generally considered safe at traditional culinary and herbal doses, but the essential oil constituent methylchavicol (estragole) is classified as a potential carcinogen at high or prolonged doses based on rodent studies, warranting caution with concentrated extracts or essential oil forms. Due to its effects on serotonergic (5-HT3) and cholinergic pathways, theoretical interactions exist with antiemetic drugs such as ondansetron and with anticholinergic medications. Pregnant and breastfeeding women should avoid therapeutic doses given insufficient safety data and the presence of pharmacologically active essential oil compounds. Individuals on anticoagulant therapy should use caution, as rosmarinic acid carries mild platelet-inhibiting properties that could potentiate bleeding risk.
Based on the mechanism and research, Agastache (Agastache rugosa) may support the following health areas. Each link goes to an evidence-ranked guide of the best ingredients for that concern.
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