Abiogen (Bacillus subtilis natto)

Abiogen is a standardized Bacillus subtilis natto fermentation-derived ingredient, primarily characterized by its enzymatic content rather than conventional macronutrient profile. Key bioactive component: Nattokinase (subtilisin NAT, EC 3.4.21.62) — typically standardized to fibrinolytic units (FU), commonly 1,000–20,000 FU per gram depending on preparation. Protein content: predominantly enzymatic protein (serine protease) comprising the bulk of the active fraction; exact percentage varies by preparation but fermented natto biomass is roughly 18–20% protein by dry weight. The nattokinase enzyme itself has a molecular weight of approximately 27.7 kDa. Bioactive compounds also include vitamin K2 (menaquinone-7, MK-7) as a co-produced metabolite of B. subtilis natto fermentation, typically in the range of 500–1,000 mcg per 100g of fermented biomass, though concentration in isolated enzyme preparations is markedly lower. Polyglutamic acid (a natural biopolymer) may be present as a fermentation byproduct. Minimal carbohydrate and fat content expected in purified enzyme concentrates. Bioavailability note: Nattokinase demonstrates documented resistance to gastric acid and pepsin degradation, with studies indicating partial survival through the GI tract; absorption of intact enzyme has been demonstrated in animal models with detectable fibrinolytic activity in plasma. Probiotic-associated metabolites (short-chain fatty acids, B vitamins including biotin and riboflavin) may be present at trace levels from the bacterial biomass.